Marijuana is the common term for cannabis that is derived from the plant Cannabis sativa. It contains hundreds of cannabinoids, which are chemicals that have many chemical components. The two main cannabinoids in the cannabis plant that we’ve studies are D9-tetrahydrocannabinol or THC and cannabidiol or CBD. CBD has mind-altering properties, while THC does not.
Cannabinoids, also known as neurotransmitters, are chemicals that alter the activity of nerves. This is why cannabis can have an effect on the body. The endocannabinoid (or endocannabinoid) system is how we make our own cannabinoids. Anandamide and 2-arachidonoyl-glycerol are the two endocannabinoids.
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Hillard CJ, Beatka M, Sarvaideo J. Endocannabinoid Signaling and the Hypothalamic-Pituitary-Adrenal Axis. Comprehensive Physiology. 2016;7(1):1-15. doi: 10.1002/cphy.c160005.
Adolescents and lower IQ
Meier MH and colleagues, Neuropsychological decline in persistent cannabis users from childhood to middle life. Proc Natl Acad Sci USA 2012;109(40):E2657-E2664
Higher risk of psychosis for people who are already at high risk of developing psychosis Nehal P. Vadhan. Cheryl M. Corcoran. Gill Bedi. John G. Keilp. Margaret Haney. Preliminary study on the acute effects of smoking marijuana among marijuana smokers who are clinically high-risk for psychosis. Psychiatry Research, 2017; 257: 372
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